CALL FOR PAPERS Intestinal Stem Cells in GI Physiology and Disease Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function
نویسندگان
چکیده
Christa N. Grant, Salvador Garcia Mojica, Frederic G. Sala, J. Ryan Hill, Daniel E. Levin, Allison L. Speer, Erik R. Barthel, Hiroyuki Shimada, Nicholas C. Zachos, and Tracy C. Grikscheit Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California; Division of Pediatric Surgery, Children’s Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, California; Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, Children’s Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, California
منابع مشابه
Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function.
Short bowel syndrome (SBS) is a devastating condition in which insufficient small intestinal surface area results in malnutrition and dependence on intravenous parenteral nutrition. There is an increasing incidence of SBS, particularly in premature babies and newborns with congenital intestinal anomalies. Tissue-engineered small intestine (TESI) offers a therapeutic alternative to the current s...
متن کاملVitamin E Improves Morphology and Absorptive Surface of Small Intestine in Broiler Chickens Reared at High Altitude
Under high altitude conditions, the effects of vitamin E (α-tocopherol) on growth performance, intestinal morphology (villus size and type), and absorptive surface area of broiler chickens were evaluated. Chickens were fed diets supplemented with 0, 100, 200 or 400 IU/kg vitamin E for 42 days. On days 14, 28 and 42, birds were sacrificed and three segments of small intestine were dissected. The...
متن کاملAnatomical, histological and histomorphometric study of the intestine of the northern pike (Esox lucius)
Background: The northern pike Esox lucius is a fresh water species belonging to the Esocidae family. It is a carnivorous fish which mostly feeds on invertebrates and fishes. The morphology of its intestine is very useful for understanding the fish’s digestive physiology, diagnosing some intestinal diseases and formulating suitable feeds. OBJECTIVES: This study was designed to determine the anat...
متن کاملGut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation.
Existing in vitro models of human intestinal function commonly rely on use of established epithelial cell lines, such as Caco-2 cells, which form polarized epithelial monolayers but fail to mimic more complex intestinal functions that are required for drug development and disease research. We show here that a microfluidic 'Gut-on-a-Chip' technology that exposes cultured cells to physiological p...
متن کاملCALL FOR PAPERS Intestinal Stem Cells in GI Physiology and Disease Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture
Ramalingam S, Daughtridge GW, Johnston MJ, Gracz AD, Magness ST. Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture. Am J Physiol Gastrointest Liver Physiol 302: G10–G20, 2012. First published October 13, 2011; doi:10.1152/ajpgi.00277.2011.—Sox9 is an high-mobility group box transcription factor that is expressed in the stem cell zone of the small...
متن کامل